For Veterinarians
Welcome to our website. We would like to introduce you to the treatment for canine B cell lymphoma that we have been working on for the past decade. We are using autologous T cells from a peripheral blood sample, isolating the T cells, selecting and growing the cells to increase the numbers exponentially and to activate them to be responsive to the antigens presented by the tumor cells.
If you and your client decide to utilize the T cell therapy, it requires that you send us a 20ml blood sample collected (purple top tubes), shipped overnight, chilled, but not frozen. We will isolate the T cells and grow them under specific culture conditions that will select the cells most responsive to the tumor antigens. After 14-21 days, the culture will be maximally expanded and will be shipped back overnight where it will need be infused within 4 hours of receiving it. With the first infusion only, the patient will receive an oral dose of cyclophosphamide to prepare for the T cell infusion.
Please call us at any time so we can answer any questions and explain the process in greater detail.
Further Reading
Adoptive T-cell therapy improves treatment of canine non-Hodgkin lymphoma post chemotherapy
Scientific Report
2012 Feb 13;2:249
Man’s best friend: What can pet dogs teach us about non-Hodgkin’s lymphoma?
Immunology
Rev 2105 Jan;263(1):173-91
Anti CD19 chimeric antigen receptor-modified T cells for B cell malignancies: a systemic review of efficacy and safety in clinical trials.
European Journal of Haematology
2016 Apr;96(4):389-96
IL-21 induces proliferation and modulates receptor expression and effector function in canine natural killer cells.
Veterinary Immunology and Immunopathology
2015 MAY 15;165(1-2)22-33